Release from maternally-induced allotypic suppression in rabbit by Nocardia water-soluble mitogen

نویسندگان

  • C Bona
  • P A Cazenave
چکیده

The in vitro synthesis of allotypes of b4/b5 offspring obtained from b4/b4 mothers immunized against paternal allotype b5/b5 was studied in comparison to similar offspring that had escaped from suppression and normal heterozygous b4/b5 rabbits. Nocardia water-soluble mitogen-a rabbit B-cell mitogen which is known to induce the differentiation of small lymphocytes into plasma cells and polyclonal activation of Ig, was able to break in vitro the allotypic suppression induced in vivo.

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 146  شماره 

صفحات  -

تاریخ انتشار 1977